The Historic Tolovana Roadhouse is located between Nenana and Manley Hot Springs, at the confluence of the Tanana and Tolovana rivers in interior Alaska. The Roadhouse has served as a safe haven for interior travelers for over one hundred years. Most famous as the first exchange station for diphtheria antitoxin as sled dog teams relayed the serum from Nenana to Nome during the The Serum Run of 1925, an event which later inspired the Iditarod Trail Sled Dog Race, the Tolovana Roadhouse is one of only two remaining roadhouses on the Nenana-Nome mail trail. When the Iditarod was re-routed to start in Fairbanks due to lack fo snow in 2015 and 2017, the Roadhouse served as a hospitality stop for race teams on their way to Nome.